Oxyntomodulin increases intrinsic heart rate through the glucagon receptor
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منابع مشابه
Oxyntomodulin increases intrinsic heart rate through the glucagon receptor
Two hormones from the gastrointestinal tract, glucagon and oxyntomodulin (OXM), vigorously elevate the intrinsic heart rate (IHR) of mice. We have previously shown that OXM influences murine heart rate (HR) independent of the glucagon-like peptide 1 (GLP-1) receptor. Here, we demonstrate using radiotelemetry in mice deficient in the glucagon receptor (Gcgr -/-) that both OXM and glucagon requir...
متن کاملOxyntomodulin increases intrinsic heart rate in mice independent of the glucagon-like peptide-1 receptor.
Oxyntomodulin (OXM), a postprandially released intestinal hormone, inhibits food intake via the glucagon-like peptide-1 receptor (GLP-1R). Although OXM may have clinical value in treating obesity, the cardiovascular effects of OXM are not well understood. Using telemetry to measure heart rate (HR), body temperature (Tb), and activity in conscious and freely moving mice, we tested 1) whether OXM...
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The glucagon-like peptide (GLP)-1 receptor is a promising target for the treatment of type 2 diabetes and obesity, and there is great interest in characterizing the pharmacology of the GLP-1 receptor and its ligands. In the present report, we have applied bioluminescence resonance energy transfer assays to measure agonist-induced recruitment of arrestins and G-protein-coupled receptor kinase (G...
متن کاملInvestigating the Glucagon Receptor and Glucagon-Like Peptide 1 Receptor Activity of Oxyntomodulin-Like Analogues in Male Wistar Rats
AIMS To investigate the effect of Glu-3 OXM-like analogues on food intake and bodyweight in male rats. BACKGROUND Oxyntomodulin (OXM) is a natural agonist at both the glucagon receptor (GCGr) and the glucagon-like peptide 1 receptor (GLP-1r), and peripheral administration reduces food intake and increases energy expenditure in rodents and humans. Substituting the native glutamine (Gln) at ami...
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ژورنال
عنوان ژورنال: Physiological Reports
سال: 2013
ISSN: 2051-817X
DOI: 10.1002/phy2.112